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Obviously, the overexpression by multicopy plasmid increased the transcription level by increasing its copy number

New strategies for the development of antifungal drugs have gradually become a research hotspot, including the targeting of novel biological pathways, the combination of antifungal drugs, the development of fungal vaccines, the creation of innovative therapeutics (such as small-molecule peptides and nanoparticles), the extraction of active ingredients from traditional Chinese medicine, and the utilization of artificial intelligence in drug design ( Figure 1 ) (Wall and Lopez-Ribot, 2020