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Ongoing structure-activity relationship studies focus on optimizing chelate stability and tumor penetration, with heterobimetallic complexes and nanoparticle formulations showing particular promise for enhancing bioavailability and reducing off-target effects [125]

172 The expression of itaconate, a mitochondrial metabolite with antimicrobial and antiinflammatory functions that accumulates when the Krebs cycle is disrupted, is upregulated in murine models of asthma 173 where it suppresses both proinflammatory (M1) and alternatively activated (M2) macrophages