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44,45 Estrogen appears to modulate pain perception in multiple ways, including through effects on nerve pathways and neurotransmitter function, influencing serotonin, dopamine, epinephrine, and endogenous opioid signaling

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These murine models were then presented with BPC-157 to illustrate its action

doi: 10.1016/j.clinbiochem.2010.02.011