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Recently, a new DON prodrug, DRP-104 (sirpiglenastat) was developed, which carries isopropyl ester and acetylated tryptophan on the C-terminal and N-terminal of DON (Rais et al., 2022)

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This strategy helps in enhancing the effectiveness and the bio-accessibility of the drug

therefore, the study of p62 and miRNAs could be a key research direction in the future

Therefore, they concluded that vitamin E supplements appear to be safe for most adults in amounts 1600 IU (1,073 mg/day)

Rooibos tea, garlic, and fish oil appear to induce the activity of CYP3A, 3A1, and 3A2 [32]