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In addition, CaMKII binds to MEK1/2 and ERK1/2 to form macromolecular complexes to synergistically promote the phosphorylation of ERK1/2 at Thr202/Tyr204 and nuclear translocation 56

Borkowska, M

11-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial

The pro-oxidative effect of VIC is associated with the reduction of transitional metals (e.g., Fe 3+ and Cu 2+ ), and hydrogen peroxides appearance leads to free radicals formed by Fenton and HaberWeiss reactions