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While transient activation of cGASSTING is protective against pathogens, chronic or dysregulated activation by endogenous mtDNA in aging or neurodegeneration becomes maladaptive

At the molecular signaling level, the combination produces simultaneous activation of pathways that are normally activated in sequence during natural wound healing

However, oral absorption is extremely poor rendering intravenous administration the preferred route

Diabetes Res Clin Pract 2020;166:108308.ArticlePubMed 78

DEM-induced GSH depletion causes lipid peroxidation-induced cell death in hepatocyte [113]