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This complex initiates a cascade that leads to the activation of downstream executioner caspases, such as caspase-3, which ultimately drive the apoptotic process [136]

Pituitary (2022) 25:882890

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It has been documented that patients with active CD had up-regulated NOS mRNA expression in their colonic mucosa and peripheral blood mononuclear cells (164)

33 GENERAL APPROACH: IDENTIFY, CONFIRM, GIVE SUPPORTIVE CARE The most important clues for identifying and differentiating among deadly drug rashes are in the history, timing of exposure, and the bedside physical examination