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Eur J Cancer 2006

Mice on HFD exhibit increased markers of oxidative damage (e.g., 8-OHdG, lipid peroxidation), disrupted follicular growth, and diminished fertility outcomes, providing robust platforms to test therapeutic strategies targeting metabolic inflammation and oxidative pathways (Gonnella et al., 2022

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To support these results, we also examined protein expression of IR and IGF-1R following CD4 + T cell activation using immunoblot and found that IR protein levels were unchanged following CD4 + T cell activation, whereas IGF-1R protein levels were indeed upregulated following activation and accumulated over time (Fig