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Although three classes of RNR with various known permutations have been described, the enzyme likely arose only once, as all known RNR enzymes appear to share a common ancestor [35]

Moreover, in a scoping review, the use of psychotropics for neurocognitive disorders, including BD, SZ, MDD or obsessive-compulsive disorder, could exert important antimicrobial effects on gut microbiota [210]

The aim is to discover more effective and targeted inhibitors for the treatment of digestive tumors

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Specifically, weight gain has been associated with both INSTI and TAF use in both clinical trials and real-world observational studies [5, 31,32,33,34], while weight loss has been associated with use of TDF and EFV [2,3,4]

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