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May 6 2021;18(9)doi:10.3390/ijerph18094955

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Nevertheless, this increased autophagic activity becomes compromised in the presence of diabetes, both in living organisms and under elevated glucose conditions in laboratory settings ( Numerous reports indicate that uremic waste can contriute to mitochondrial dysfunction and hypermethylation of the Klotho gene, both of which are pivotal in the senescence of DN cells (Sun et al., 2017