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This reduced activity, combined with a potentially slower metabolism that can occur with persistent nutrient deficiencies, could indirectly contribute to weight gain over time

Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, et al

Research shows that the output of new T-cells falls from roughly 20% in youth to less than 1% after age 50 , meaning the body produces far fewer fresh immune cells to replace the ones that naturally wear out over time