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Hypoxia and inner retinal neural changes have been reported at 2 weeks and the earliest vascular changes (leakage of fluid from retinal capillaries) can only be seen after 4 weeks

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In IBS-C, pain is considered a core diagnostic feature, whereas in FC, its presence is more variable and less well-characterized

Downstream reaction that forms cysteine from cystathionine by cystathionase (CTH) has also been recently described to play a key role in adaptation mechanisms during cysteine-deprived induced stress in a wide variety of cancer cells lines (55)

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