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COPD progression is often not ameliorated by current therapies in many patients, given that they target either free radicals or inflammatory responses independently, as opposed to addressing both simultaneously [136]

Chronic fluoxetine treatment directs energy metabolism towards the citric acid cycle and oxidative phosphorylation in rat hippocampal nonsynaptic mitochondria

On the other hand, enhancing the systems function could be beneficial in degenerative diseases where ferroptosis contributes to pathology, such as neurodegenerative diseases, which are mostly associated with oxidative stress and cell death