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Urology 2021

[8] [19] Therefore, depending on the cells current demand for ATP, NADPH, and ribose 5-phosphate , reactions from glycolysis and the pentose phosphate pathway can be strategically combined to prioritize the synthesis of specific metabolites

Furthermore, mutation of the isocitrate dehydrogenase 1 gene in low-grade gliomas causes production of D-2-hydroxyglutarate, a steric analogue of glutamate

ALS pathogenic mutations identified in RNA-binding proteins (RBPs) include TAR DNA binding protein 43 (TDP-43), fused-in-sarcoma (FUS), Ewing sarcoma (EWS), TATA-binding protein-associated factor 15 (TAF15), and heterogeneous nuclear ribonucleoproteins (hnRNPs) 5,6