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The endothelial Nrf2 can be triggered via increased reactive oxygen species production and PI3K-Akt signalling induced by shear stress (Reference Chen, Varner and Rao85)

Ultrasound-triggered and glycosylation inhibition-enhanced tumor piezocatalytic immunotherapy

Generally, persistent M1 macrophage activation causes excessive stimulation of pro-inflammatory cytokines to release, causing an imbalance of colonic homeostasis and barrier disruption (Lv et al., 2021), 1,25-dihydroxyvitamin D3 (Long et al., 2022), loganin (Liu et al., 2020), methyl gallate (Zhou et al., 2022), platycodin D (Guo et al., 2021), triptolide (Tang et al., 2020), and tiliroside (Zhuang et al., 2021) suppresses M1 macrophages activation and promote M2 macrophages, thereby alleviating UC

Figure 4 Induction of M1 M M is an essential component of the innate immune system and the first line of defense against parasitic infections

RV: Funding acquisition, Conceptualization, Writing review and editing

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