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We found that PSEN1 and APOE4/4 or APOE3/4 confer different phenotypes in human fibroblasts, similarly to that reported in iPSC-derived human microglia

N-Terminal acetylation of -Synuclein slows down its aggregation process and alters the morphology of the resulting aggregates

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In the absence of vitamin D, the activity of TRPH1 (the non-neuronal form) that is responsible for peripheral serotonin production is enhanced (in contrast to the brain TRHP2), which contributes to an exaggerated immune response, gut motility and bone resorption

Arjun Saha, University of Southern California

doi: 10.1016/j.brainres.2015.06.017 162 KongCHChoKMinJWKimJYParkKKimDYet al