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The p53 gene is widely recognized as a tumor suppressor gene, playing a pivotal role in regulating key cellular processes, including cell cycle control, DNA repair, cell proliferation, apoptosis, aging and oxidative stress response, which are associated with diseases such as diabetes, cancer and hypertension (40,41)

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The reduction in negativity observed in B-NLPs can be attributed to the negative charge of phosphate groups in the DNAzyme backbone at physiological pH 53

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