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Causes and Symptoms of B12 Deficiency Deficiency can arise from: Poor dietary intake Malabsorption issues (e.g., pernicious anemia, atrophic gastritis) Gastrointestinal surgeries or disorders (e.g., Crohns disease) Certain medications affecting stomach acid or absorption Symptoms of deficiency include fatigue, weakness, numbness or tingling in hands and feet, memory difficulties, mood changes, and in severe cases, neurological damage

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It can activate proto-oncogenes and cause dysplasia [19]

Specific genetic mutations that cause abnormal protein accumulation cause neurodegenerative diseases like Alzheimers and Parkinsons both of which are common types of dementias that arise from certain parts of the brain decaying faster than others

Nonetheless, people with this condition tend to display a range of symptoms that can be evaluated through proper testing, which can help to differentiate it from other conditions