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Description

Sardh E, Harper P, Andersson DE, Floderus Y

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doi: 10.1016/j.freeradbiomed.2018.11.033 192

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This differential expression of proteins controlling carbon metabolism may indicate uncoupling of glycolysis from oxidative phosphorylation (OXPHOS)

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This, in turn, will result in a high fidelity in-silico / in vitro liver framework that can negate the need for any further in vivo experiments for toxicity and efficacy in line with the goals of the 3 R principles 54 and the recent push towards using diseases/organs-on-chips 32,55 for drug screening purposes

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