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O., Yasoshima A., Yoshikawa H., Yoshikawa T., Okaniwa A

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The subjects were divided into four treatment groups: [1] Control group (vehicle) Low-dose paraxanthine (equivalent to 25mg human dose) High-dose paraxanthine (equivalent to 100mg human dose) High-dose caffeine (equivalent to 100mg human dose) To assess cognitive function, the researchers employed the Morris water maze test , a well-established method for evaluating spatial learning and memory

doi: 10.1111/j.1365-2222.2010.03531.x 104 LarabiABMassonHLPBumlerAJ

therefore, use is not advised

Based on the function of Tregs and their ability to induce cytokine immunosuppression, researchers consider treating AR by increasing IL-10, TGF-, and IgG4 levels and Treg cell counts to induce immune tolerance [105]