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The spatial pattern of pressure-induced injury of RGCs correlates with the location of their axons within the ONH whereas other classes retinal neurons tend to be (at least initially) spared from IOP-induced injury (Figure 5) (8, 54)

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In vitro assays involving the addition of p300 and bhb-CoA demonstrated an increase in Kbhb sites on core histones, indicating that p300 functions as a histone Kbhb transferase on nucleosomes and can directly modulate transcription (Huang et al., 2021)

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