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High B12 often indicates underlying pathology including hepatic disease, renal impairment, or myeloproliferative disorders

22 Loguercio et al

Radwanski, K., Thill, M

The disorders clinical manifestations of these disorders are typically nonspecific and may present with multisystemic symptoms [2], including psychomotor retardation, hypotonia, microcephaly, and metabolic acidosis

In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c cystine-glutamate exchanger

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