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The isolated hearts from the IRI groups underwent 25 min of aerobic stabilization, 22 min of global noflow ischaemia (by a cessation of the buffer flow), and 30 min of reperfusion (aerobic conditions) in the presence or absence of Klotho protein

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In one example, GSH-driven nanoparticle disintegration releases indomethacin to inhibit PTGS2 while reducing Pt 4 + to cytotoxic Pt 2 + , thereby amplifying cisplatin-induced pyroptosis in pancreatic cancer 218

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