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This receptor-level enhancement represents a more elegant biological approach

PLOS ONE , 5(9), e12684

doi: 10.1136/annrheumdis-2014-206106 43 SchaferPHKivitzAJMaJKorishSSutherlandDLiLet al

Two properties of the native peptide make it impractical as a durable pharmacological agent

48 Together with the diversity of ubiquitin linkage types, this architectural variability gives the UPS its extraordinary precision, enabling tight regulation of proteostasis and preventing the accumulation of toxic proteins under physiological and pathological stress