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In a diet-induced NASH rat model, administration of 1,25 VD3 was shown to reshape the hepatic cytokine milieu by suppressing pro-inflammatory mediators such as TNF- and IL-1, while simultaneously enhancing anti-inflammatory cytokines, including IL-10 and IL-4

The fastest approaches include: reducing dietary histamine intake immediately (avoid aged, fermented, and leftover foods), taking vitamin C, which research shows can support healthy blood histamine levels by up to 38% 26 , using a HEPA air purifier to reduce environmental triggers, and nasal saline irrigation to physically remove irritants

Probiotics also affect the activity of various immune cells, including dendritic cells, macrophages, and T cells, enhancing the guts ability to respond appropriately to pathogens (109)

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10.1016/j.ijvsm.2018.09.001 141

Syndrome of Cholestasis Definition Cholestasis is impaired formation or flow of bile