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These findings highlight novel insights into ferroptosis in malignant tumors ( In vitro experiments demonstrated synergistic antitumor efficacy of erastin and doxorubicin, mediated by GPX4 degradation and excessive ROS production, which collectively reduced viability of NCI-H929 and RPMI-8226 cells ( 2+ levels, and disrupts iron homeostasis, thereby promoting ferroptosis

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Ripk1 D138N/D138N hepatocytes substantially blocked apoptosis and RIPK1 activation induced by TNF alone or TNF/CHX (Fig