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Evidence Quality: Very High

Traditional drug delivery methods, such as systemic administration, often require high doses to achieve effective concentrations in the brain, which not only increases the drugs toxic side effects but also limits its clinical application

10.1095/biolreprod43.5.870 [DOI] [PubMed] [Google Scholar] 10.Miao YL, Kikuchi K, Sun QY, Schatten H

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