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Moreover, several NSCLC lines exhibited a significant elevation in maximal respiratory capacity that could not be explained by an increase in mitochondrial density (Fig

Inhibition of GCS It is well known [27, 41] that GSH is a competitive inhibitor against glutamate of GCS, the enzyme that catalyzes the synthesis of glutamyl-cysteine

In the chondrocytes of the iron overload model, the levels of GPX4 and SLC7A11 within the antioxidant system were lower, whereas lipid peroxidation levels, indicated by 4-HNE, were higher, and their mitochondria exhibited characteristics similar to ferroptosis (175)

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Reduced glutathione oxidizes rapidly in liquid form, losing 40% potency within 14 days even under refrigeration