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56 However, if the patient continues to present evidence of liver dysfunction beyond persistent ALT elevation (satisfying KCH criteria of acidosis, elevated creatinine, hyperbilirubiniemia, coagulopathy and encephalopathy), then NAC therapy should be continued as these indicators portend a poor prognosis regardless of transaminase levels

Brain Behav Immun 87:3439

This restriction is due to the rigid nature of the amide (peptide) bond

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It had long been hypothesized that antioxidants might be able to protect against cancer because they neutralize reactive oxygen species (ROS) that can damage DNA