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That statement surprises people who think of their skeleton as a static framework, but bones are dynamic organs with blood supply, nerve innervation, and continuous cellular turnover

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Mechanistically, aberrant copper homeostasis during I/R impairs Fe-S cluster integrity, increases ROS production, and depletes GSH, culminating in synergistic proteotoxic and oxidative damage [160]

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Your provider should reassess your B12 levels periodically typically every 3 to 6 months to determine whether continued injections are warranted or whether oral supplementation is sufficient to maintain adequate levels

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