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In ME/CFS and Long COVID, researchers have identified a 'mitochondrial-peroxisomal vicious cycle.' As mitochondria attempt to generate adenosine triphosphate (ATP) for energy, damaged electron transport chains 'leak' electrons, creating highly reactive superoxide radicals

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It is thought that fresh, edibles, and teas made from the live plant leaves can be the most effective ways to use these for providing relief

Finally, the ion gradient disruption may cause a reversal of transporter functioning, which contributes to an additional increase of glutamate levels in the ECS (Allen et al., 2006