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Additionally, CBS and CSE are key enzymes regulating H 2 S production in the brain through the TSP, and they have been used as important targets to stimulate the TSP, thus reducing oxidative stress and inflammation, and improving brain function 9,60

Primers used for vector construction were listed in Supplementary Table 12

Nicholls et al, 1993)

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The name of the repository and accession number can be found below: National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA), project number is: PRJNA1170518