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The review also highlighted how GHK-Cu was linked to new blood vessel formation (angiogenesis) and better organization of the extracellular matrix, or the scaffolding that holds skin and tissue together

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The arrestin-receptor complex may be unable to couple to downstream G proteins, but it can mediate other signaling and it also may be removed from the plasma membrane by clathrin-mediated endocytosis, a true down regulation of receptor protein

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J Exp Bot 56(422):30413049 Kangasjrvi S, Neukermans J, Li S, Aro EM, Noctor G (2012) Photosynthesis, photorespiration, and light signalling in defence responses