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Hernia 2008;12:299-302

Interestingly, the weight loss effect of AOD-9604 did not follow the usual "more is better" principle

M.et al

This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity