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Circulatory & nerve health

As deduced from an X-ray crystallographic analysis of 43 in complex with ERAP2 it was concluded that the three first specificity pockets of the enzyme was of particular importance for binding to the enzyme (Zervoudi et al., 2013)

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To maintain nitrogen homeostasis in the brain and the whole organism, glutamate is required, functioning as a substrate and a product of several enzymes

Hu S, Shao C

This suggests that B12 has an influence over our circadian rhythm, however researchers are yet to determine the exact connection