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Participants first lost weight during a 36-week lead-in period on tirzepatide, then were randomized to either continue the medication or switch to placebo for an additional 52 weeks

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Methionine in turn is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA, RNA, and proteins ( Figure 1 ) (3)