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Hepcidin, a hormone primarily synthesized and secreted by hepatocytes, binds to and degrades FPN, leading to intracellular iron retention and a decrease in circulating iron levels [21, 22]

GPT2, a ferroptosis-related gene, catalyzes the reversible reaction between alanine and -KG to generate pyruvate and glutamate [77, 78]

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This can include redness, swelling, tenderness, or slight bruising

20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide

In an effort to evaluate the signaling mechanism responsible for the observed cardioprotection, they demonstrated that exogenous H 2 S ameliorated myocardial ischemia-reperfusion injury in db/db diabetic mice by activating Nrf2 signaling in an ERK1/2-dependent manner (Peake et al., 2013)