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As members of the xenobiotic-metabolizing enzymes family, OMEs have been initially involved in the clearance and deactivation of the odorants from the perireceptor environment, which are necessary to maintain the sensitivity of odorant detection by the olfactory receptors 1

Gut microbial-derived SCFAs can play a crucial role in anti-inflammatory actions through direct and indirect mechanisms, as they maintain gutbrain permeability and sustain inputs to the CNS to maintain microglia homeostasis (209)