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Second, we classified the subjects with a past history of smoking but without smoking at baseline ( n = 996) as non-smokers, which might have influenced our findings

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Thats because, at the time, Japan had no legally-binding regulations regarding tobacco consumption

ASSOCIAO DO POLIMORFISMO DO GENE LIGANTE DE MORTE PROGRAMADA-1 (PD-L1) COM O CNCER DE MAMA Diego de Arago Bezerra, Francisco das Chagas Medeiros, Janssen Loiola Vasconcelos, Anderson Weiny Barbalho Silva, Ernando Igo Teixeira de Assis, Yuri Matos de Arago Bezerra, Trcilla Pinto Passos Bezerra, Jos Juvenal Linhares REVISTA FOCO 3