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There are more than 60 mutated genes that might cause AS

10.1038/sj.bjc.6604485 30 LuoL.HuangF.ZhongS.DingR.SuJ.LiX

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The impairment of mucociliary function caused by pyocyanin-induced ROS leads to the accumulation of mucus, creating a niche for chronic microbial infection and vicious cycles of inflammation (79), particularly relevant in chronic respiratory diseases such as CF and COPD, where P

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As the RPE is a non-dividing cell type, the loss of RPE is permanent, inevitably leading to photoreceptor cell death and visual abnormalities, including central vision loss [24,25,26,27]