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High-expression miR-126 induces IgE-mediated mast cell degranulation related to PI3K/AKT signaling by increasing Ca 2+ influx

This is achieved mainly by contributing to the methionine cycle (Zhou et al., 2017) and the SIRT1 pathway (Zhou et al., 2018b), inhibiting hypermethylation of promoter associated with GSH synthesis-related genes, and activating the adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) pathway (Zhou et al., 2018a)

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60 WangB.FengL.JiangW.-D.WuP.KuangS.-Y.JiangJ.et al

Each mushroom targets a different inflammatory pathway