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International Journal of Cosmetic Science 30(2):87-95. [doi.org]

Tricyclic antidepressants (TCAs) Amitriptyline and nortriptyline: Effective in managing PDPN by inhibiting monoamine reuptake and blocking sodium channels

VDAC2 is an important component of the mitochondrial apoptotic signaling cascade [203] and is activated by SNO [204]

These include metabolism regulation, stress responses, and aging biology

doi: 10.1016/j.bbr.2018.12.052 85 UchigashimaMLeungMWatanabeTCheungALeTPallatSet al

It has received FDA Breakthrough Therapy designation for MASH (metabolic dysfunction-associated steatohepatitis), the liver condition formerly known as NASH