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Research shows that subjects using IGF-1 LR3 during a 20% caloric deficit while maintaining high protein intake lost fat without measurable lean mass reduction, whereas those with protein intake below 1.6 g/kg showed no advantage over placebo

Intermittent hyperoxic exposures induce many of the physiological responses that occur during hypoxia (Cimino et al., 2012)

Still, as metformin inhibits the respiratory chain complex I, and FH deficiency leads to a decreased OXPHOS activity, it is unclear whether this treatment would be beneficial [118]