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For example, a lack of both iron and folate can cause severe anemia

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The double combination ((M+D)/2) significantly increased toxicity in IMR-32 and IMR-5/75 cells within 24 hours, persisting up to 72 hours

The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia)