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Jin M, Wei Y, Yu H et al (2021) Erythritol improves nonalcoholic fatty liver disease by activating Nrf2 antioxidant capacity

Reducing the amount of GSH in cells can greatly increase the sensitivity of cancer cells to CDDP

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doi: 10.1016/j.molcel.2014.04.024 175 JiangPDuWWangXMancusoAGaoXWuMet al

Several mechanisms have been reported for the increased activity of NRF2 in cancers ( Figure 5 ): (1) somatic mutations in KEAP1 or NRF2 , (2) DNA hypermethylation at the promoter region of KEAP1 , (3) the aberrant accumulation of proteins that disrupt the KEAP1NRF2 interaction, (4) transcriptional up-regulation of NRF2 gene through oncogene-dependent signaling, and (5) the modification of KEAP1 protein through oncometabolites

Vitamin C is a powerful antioxidant that helps neutralize oxidative stress, potentially supporting long-term skin health