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When levels are low, it can lead to confusion, forgetfulness, and even mood changes, such as depression or irritability

Visible physique changes (lean mass or fat loss) often occur after 68 weeks of consistent use

Other non-insulin mechanisms of hepatic GH resistance in anorexia nervosa have also been described, including fibroblast growth factor-21, sirtuin 1, triiodothyronine, leptin and testosterone (63)

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