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Thus, using two assays with complementary dynamic ranges of efficacy readouts, we showed that fluorination in the 11-position markedly reduces MOR signaling efficacy of an already low-efficacy agonist, the parent 7OH

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During the initial treatment period, 18 (1.6%) of patients treated with fondaparinux sodium and 10 (0.9%) of patients treated with enoxaparin sodium had a VTE endpoint (95% CI for the treatment difference [fondaparinux sodium-enoxaparin sodium] for VTE rates: -0.2%

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