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Description

Pegvisomant increases the metabolic rate of food-deprived mice To assess whether the energy-conserving effects of GH can be pharmacologically manipulated, we tested in mice the effects of a clinically available GHR antagonist (pegvisomant)

J.ChangJ.ChungJ.Caspell-GarciaC.et al

However, subsequent larger studies failed to replicate these results (Yoritaka et al., 2016)

Additionally, an active, not recruiting Phase I/II study, (NCT03491683) is evaluating the safety of INO-5401 (a combination of three separate DNA plasmids targeting hTERT, Wilms tumor gene-1 antigen, and prostate-specific membrane antigen) in patients with a glioblastoma tumor with an unmethylated MGMT promote