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No clinical trial has tested the exact combination, but the closely related CagriSema (cagrilintide + semaglutide) Phase 3 trial showed that adding amylin to a GLP-1 backbone improves weight loss

doi: 10.3389/fimmu.2024.1395786 154 AthanasiosZBorisNLorenzoVNorikoGKimATWenchaoLet al

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This of course does not substitute for a diet, but aids in a weight loss plan

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