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Widespread organ failure can be caused by these circulating cytokines and oxidative neuronal damage, glial cell activation, and disruption of the BBB, which leads to neuroinflammation

The lithium-treated group also had fewer conversions from mild cognitive impairment to AD, but this number was statistically insignificant

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doi: 10.1006/bbrc.1999.0255 227 TschritterOFritscheAThamerCHaapMShirkavandFRaheSet al

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